Metabolic

Setmelanotide

Imcivree / RM-493

Peptide length
8 amino acids

Cyclic peptide

Research contextDefined therapeutic evidence

Read the linked studies for their methods and limitations.

An MC4-receptor agonist used for specific causes of obesity. The 2026 FDA label includes acquired hypothalamic obesity alongside defined genetic conditions.

Family
Melanocortin receptor agonist
Research frame
Melanocortin 4 receptor
Molecular format
Cyclic peptide

Read the evidence

Eligibility depends on the exact labeled condition and age group. This is not evidence for general obesity treatment.

Resolve the identity

Distinguish setmelanotide from other melanocortin agonists; shared receptor language does not imply the same clinical indication.