Ibutamoren (MK-677)
MK-677 / MK677
- Molecular form
- Small molecule
Small molecule
Open the sources to check how the studies were done and what they can support.
An oral ghrelin mimetic studied in a randomized trial of hormone levels, body composition and function in older adults.
- Family
- Nonpeptide ghrelin mimetic
- Research target
- Ghrelin receptor (GHSR)
- Molecular form
- Small molecule
What to know about the research
In an older-adult trial, increased fat-free mass did not translate into improved strength or function; glucose and insulin sensitivity also changed.
Check the exact compound
The cited trial used oral MK-677. Its results do not establish equivalence with another growth-hormone secretagogue.
What supports this entry?
3 of 3 summary statements linked to checked source passages.
These are selected references, not a complete review of the literature. Source checks were assisted by AI and have not received independent expert review.
Research stage, study quality and regulatory status answer different questions. A study card does not establish treatment benefit or approval.
Check the overview statementSource checked
An oral ghrelin mimetic studied in a randomized trial of hormone levels, body composition and function in older adults.
Abstract: Design, Participants, Measurements, Results and Limitation
- Selected primary-source passages checked with AI assistance. Scope cautions are editorial interpretations; this is not a complete literature review.
Check the evidence limitationSource checked
In an older-adult trial, increased fat-free mass did not translate into improved strength or function; glucose and insulin sensitivity also changed.
Abstract: Design, Participants, Measurements, Results and Limitation
- Selected primary-source passages checked with AI assistance. Scope cautions are editorial interpretations; this is not a complete literature review.
Check the identity statementSource checked
The cited trial used oral MK-677. Its results do not establish equivalence with another growth-hormone secretagogue.
Abstract: Design, Participants, Measurements, Results and Limitation
- Selected primary-source passages checked with AI assistance. Scope cautions are editorial interpretations; this is not a complete literature review.
Inside the selected studies
Randomized, double-blind, placebo-controlled modified-crossover trial
Oral MK-677
- Who or what was studied
- Healthy adults aged 60–81
- Sample size
- 65
- Compared with
- Placebo
- Duration
- Two-year design; primary assessment at one year
- Fat-free mass increased without improvement in strength or function.
- Fasting glucose increased and insulin sensitivity decreased.
- Selected study only; source mapping is not independent study-quality appraisal.
- The authors reported insufficient power for functional endpoints.