Neuroactive

Dihexa

PNB-0408

Molecular format
Peptidomimetic

Peptidomimetic

Research contextPredominantly preclinical

Read the linked studies for their methods and limitations.

An experimental angiotensin-derived peptidomimetic. A frequently cited 2014 paper on its proposed procognitive mechanism was retracted in 2025.

Family
Angiotensin-derived peptidomimetic
Research frame
Proposed HGF/c-Met-related signaling
Molecular format
Peptidomimetic

Read the evidence

Retracted work must not be treated as affirmative evidence. Independent replication is needed before accepting mechanistic or cognitive claims.

Resolve the identity

Dihexa is not angiotensin IV itself. Identity does not resolve the reliability of a paper studying it.